Antimicrobial Assessment of Resins from Calophyllum Antillanum and Calophyllum Inophyllum
Identifieur interne : 000F81 ( Main/Exploration ); précédent : 000F80; suivant : 000F82Antimicrobial Assessment of Resins from Calophyllum Antillanum and Calophyllum Inophyllum
Auteurs : Osmany Cuesta-Rubio [Équateur] ; Ahmad Oubada [Cuba] ; Adonis Bello [Équateur] ; Louis Maes [Belgique] ; Paul Cos [Belgique] ; Lianet Monzote [Cuba]Source :
- Phytotherapy Research [ 0951-418X ] ; 2015-12.
Abstract
The Calophyllum genus is well‐known for its antimicrobial and cytotoxic activities, and therefore, we analyzed these biological activities for resins of Calophyllum antillanum and Calophyllum inophyllum growing in Cuba. C. antillanum resins showed a potent activity against Plasmodium falciparum (IC50 = 0.3 ± 0.1 µg/mL), while its cytotoxicity against MRC‐5 cells was much lower (IC50 = 21.6 ± 1.1 µg/mL). In contrary, the resin of C. inophyllum showed an unspecific activity. The presence of apetalic acid, isoapetalic acid, calolongic acid, pinetoric acid I, pinetoric acid II, isocalolongic acid, pinetoric acid III, and isopinetoric acid III in C. antillanum resins was also confirmed. These results demonstrated for the first time the potential activity of C. antillanum resins against P. falciparum. Copyright © 2015 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/ptr.5506
Affiliations:
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C. antillanum resins showed a potent activity against Plasmodium falciparum (IC50 = 0.3 ± 0.1 µg/mL), while its cytotoxicity against MRC‐5 cells was much lower (IC50 = 21.6 ± 1.1 µg/mL). In contrary, the resin of C. inophyllum showed an unspecific activity. The presence of apetalic acid, isoapetalic acid, calolongic acid, pinetoric acid I, pinetoric acid II, isocalolongic acid, pinetoric acid III, and isopinetoric acid III in C. antillanum resins was also confirmed. These results demonstrated for the first time the potential activity of C. antillanum resins against P. falciparum. Copyright © 2015 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Cuba</li><li>Équateur</li></country></list><tree><country name="Équateur"><noRegion><name sortKey="Cuesta Ubio, Osmany" sort="Cuesta Ubio, Osmany" uniqKey="Cuesta Ubio O" first="Osmany" last="Cuesta-Rubio">Osmany Cuesta-Rubio</name></noRegion><name sortKey="Bello, Adonis" sort="Bello, Adonis" uniqKey="Bello A" first="Adonis" last="Bello">Adonis Bello</name></country><country name="Cuba"><noRegion><name sortKey="Oubada, Ahmad" sort="Oubada, Ahmad" uniqKey="Oubada A" first="Ahmad" last="Oubada">Ahmad Oubada</name></noRegion><name sortKey="Monzote, Lianet" sort="Monzote, Lianet" uniqKey="Monzote L" first="Lianet" last="Monzote">Lianet Monzote</name><name sortKey="Monzote, Lianet" sort="Monzote, Lianet" uniqKey="Monzote L" first="Lianet" last="Monzote">Lianet Monzote</name></country><country name="Belgique"><noRegion><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name></noRegion><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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